Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation (Q28267272)

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English	Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation	scientific article

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scholarly article

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Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation (English)

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GOA release 2020-03-11

Muscular LMNA-interacting protein

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GOA release 2020-03-11

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based on heuristic

inferred from title

object named as

Jessica Wang

2

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object named as

Yibin Wang

8

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author name string

Marie-Elodie Cattin

1

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Jonathan J Weldrick

3

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Cassandra L Roeske

4

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Esther Mak

5

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Stephanie L Thorn

6

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Jean N DaSilva

7

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Aldon J Lusis

9

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Patrick G Burgon

10

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language of work or name

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publication date

30 October 2015

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Journal of Biological Chemistry

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290

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44

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26699-714

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Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth

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20 March 2017

mTOR is a key modulator of ageing and age-related disease

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20 March 2017

Identification of a novel muscle A-type lamin-interacting protein (MLIP)

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646324

20 March 2017

mTOR: from growth signal integration to cancer, diabetes and ageing

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A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

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Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats

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Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

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CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

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7 April 2017

The failing heart--an engine out of fuel

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7 April 2017

In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of -Adrenergic Receptor Signaling

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9 May 2017

Mechanotransduction in cardiac hypertrophy and failure

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Genetics of common forms of heart failure: challenges and potential solutions

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Endurance exercise induces REDD1 expression and transiently decreases mTORC1 signaling in rat skeletal muscle

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mTOR Signaling from Cellular Senescence to Organismal Aging

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29 September 2017

Rapamycin attenuated cardiac hypertrophy induced by isoproterenol and maintained energy homeostasis via inhibiting NF-κB activation

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29 September 2017

5'-AMP-activated protein kinase increases glucose uptake independent of GLUT4 translocation in cardiac myocytes

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29 September 2017

Making new contacts: the mTOR network in metabolism and signalling crosstalk

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29 September 2017

Rapamycin: one drug, many effects

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29 September 2017

Mammalian target of rapamycin signaling in cardiac physiology and disease.

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29 September 2017

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

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29 September 2017

Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model.

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29 September 2017

The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb

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29 September 2017

Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation

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29 September 2017

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

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29 September 2017

Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation

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29 September 2017

Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins.

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Clinical and genetic heterogeneity in laminopathies.

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β-Adrenergic receptor-PI3K signaling crosstalk in mouse heart: elucidation of immediate downstream signaling cascades

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29 September 2017

Myocardial AKT: the omnipresent nexus

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Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes

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Clinical and genetic issues in dilated cardiomyopathy: A review for genetics professionals

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mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy

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29 September 2017

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

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29 September 2017

Akt/protein kinase B promotes organ growth in transgenic mice

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29 September 2017

Repeatable noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG: evaluation of tracer kinetics in a type 1 diabetes model.

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21 January 2018

Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

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Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

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Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.

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Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

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Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction

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Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure

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based on heuristic

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Transgenic remodeling of the contractile apparatus in the mammalian heart

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10.1074/JBC.M115.678433

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