Strategies for silencing human disease using RNA interference (Q28288535)

describes a project that uses

Europe PubMed Central

title

Strategies for silencing human disease using RNA interference (English)

0 references

1 reference

Daniel H Kim

1

0 references

John J Rossi

series ordinal

2

0 references

language of work or name

English

0 references

publication date

March 2007

0 references

published in

Nature Reviews Genetics

0 references

volume

8

0 references

issue

3

0 references

page(s)

173-84

0 references

1 reference

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

31 March 2020

1 reference

Unlocking the potential of the human genome with RNA interference

31 March 2020

1 reference

31 March 2020

1 reference

Gene therapy for proliferative ocular diseases

31 March 2020

1 reference

Inhibition of respiratory viruses by nasally administered siRNA.

31 March 2020

1 reference

RNAi as a treatment for HIV-1 infection.

31 March 2020

1 reference

Silencing Viral Infection

31 March 2020

1 reference

Viral-based modelling and correction of neurodegenerative diseases by RNA interference.

31 March 2020

1 reference

Prospects of RNA interference therapy for cancer

31 March 2020

1 reference

Approaches for chemically synthesized siRNA and vector-mediated RNAi

31 March 2020

1 reference

Detection of foreign RNA: implications for RNAi

31 March 2020

1 reference

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

31 March 2020

1 reference

Progress towards in vivo use of siRNAs

31 March 2020

1 reference

Mechanisms of gene silencing by double-stranded RNA

31 March 2020

1 reference

RNAi-mediated pathways in the nucleus

31 March 2020

1 reference

The role of the RNAi machinery in heterochromatin formation

31 March 2020

1 reference

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

31 March 2020

1 reference

Role for a bidentate ribonuclease in the initiation step of RNA interference

31 March 2020

1 reference

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

31 March 2020

1 reference

Argonaute2 is the catalytic engine of mammalian RNAi

31 March 2020

1 reference

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

31 March 2020

1 reference

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

31 March 2020

1 reference

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

31 March 2020

1 reference

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

31 March 2020

1 reference

RNA interference is mediated by 21- and 22-nucleotide RNAs

31 March 2020

1 reference

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome

31 March 2020

1 reference

A microRNA in a multiple-turnover RNAi enzyme complex

31 March 2020

1 reference

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

31 March 2020

1 reference

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

31 March 2020

1 reference

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

31 March 2020

1 reference

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

31 March 2020

1 reference

MicroRNA-directed cleavage of HOXB8 mRNA

31 March 2020

1 reference

MicroRNA genes are transcribed by RNA polymerase II

31 March 2020

1 reference

RNA polymerase III transcribes human microRNAs

31 March 2020

1 reference

The nuclear RNase III Drosha initiates microRNA processing

31 March 2020

1 reference

The Microprocessor complex mediates the genesis of microRNAs

31 March 2020

1 reference

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

31 March 2020

1 reference

Nuclear export of microRNA precursors

31 March 2020

1 reference

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

31 March 2020

1 reference

The role of PACT in the RNA silencing pathway

31 March 2020

1 reference

31 March 2020

RNAi: RISC gets loaded.

1 reference

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

31 March 2020

1 reference

Second-generation shRNA libraries covering the mouse and human genomes

31 March 2020

1 reference

Small interfering RNA-induced transcriptional gene silencing in human cells

31 March 2020

1 reference

Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells

31 March 2020

1 reference

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing

31 March 2020

1 reference

Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation

31 March 2020

1 reference

The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells

31 March 2020

1 reference

Gene expression: long-term gene silencing by RNAi

31 March 2020

1 reference

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

31 March 2020

1 reference

Synthetic shRNAs as potent RNAi triggers.

31 March 2020

1 reference

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

31 March 2020

1 reference

A system for stable expression of short interfering RNAs in mammalian cells

31 March 2020

1 reference

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

31 March 2020

1 reference

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

31 March 2020

1 reference

MicroRNAs: expression, avoidance and subversion by vertebrate viruses

31 March 2020

1 reference

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

31 March 2020

1 reference

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

31 March 2020

1 reference

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

31 March 2020

1 reference

Interactions between double-stranded RNA regulators and the protein kinase DAI

31 March 2020

1 reference

Antiviral innate immunity pathways.

31 March 2020

1 reference

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

31 March 2020

1 reference

Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase

31 March 2020

1 reference

Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro

31 March 2020

1 reference

Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

31 March 2020

1 reference

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

31 March 2020

1 reference

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

31 March 2020

1 reference

siRNA function in RNAi: a chemical modification analysis

31 March 2020

1 reference

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

31 March 2020

1 reference

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

31 March 2020

1 reference

RNAi-mediated gene silencing in non-human primates.

31 March 2020

1 reference

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

31 March 2020

1 reference

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

31 March 2020

1 reference

Aptamer mediated siRNA delivery

31 March 2020

1 reference

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

31 March 2020

1 reference

Lentiviral-mediated delivery of siRNAs for antiviral therapy

31 March 2020

1 reference

Therapeutic short hairpin RNA expression in the liver: viral targets and vectors

31 March 2020

1 reference

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

31 March 2020

1 reference

siRNA-directed inhibition of HIV-1 infection

31 March 2020

1 reference

Modulation of HIV-1 replication by RNA interference

31 March 2020

1 reference

Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference

31 March 2020

1 reference

RISC is a 5' phosphomonoester-producing RNA endonuclease

31 March 2020

1 reference

The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.

31 March 2020

1 reference

Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy

31 March 2020

1 reference

Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

31 March 2020

1 reference

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

31 March 2020

1 reference

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

31 March 2020

1 reference

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

31 March 2020

1 reference

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

31 March 2020

1 reference

Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery

31 March 2020

1 reference

Knocking down disease with siRNAs

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRG2006

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1029198606

0 references

Fatcat ID

release_7h3jpllm3ff4hnvk6vqwi4czre

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

17304245

1 reference

Consolidated OpenCitations Corpus – April 2017