Correlation between the biochemical pathways altered by mutated Parkinson-related genes and chronic exposure to manganese (Q23914777)

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25 September 2023

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Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration

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Manganese efflux in Parkinsonism: insights from newly characterized SLC30A10 mutations

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Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter.

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Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

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Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primates.

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α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson disease

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ATP13A2 (PARK9) polymorphisms influence the neurotoxic effects of manganese

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Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects

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The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells.

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Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity

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LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

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Ubiquitin is phosphorylated by PINK1 to activate parkin

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DJ-1 has a role in antioxidative stress to prevent cell death

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

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Activation of JNK pathway and induction of apoptosis by manganese in PC12 cells.

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The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

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Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

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R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

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Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function

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Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells

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Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein

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Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 protein

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Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

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PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

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PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation

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PINK1 protein in normal human brain and Parkinson's disease

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Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

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Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

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Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

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Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling

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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

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Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death

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PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

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7 January 2021

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Manganese induces oxidative impairment in cultured rat astrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Molecular basis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Novel mutation in ATP13A2 widens the spectrum of Kufor-Rakeb syndrome (PARK9).

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Parkin attenuates manganese-induced dopaminergic cell death

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer

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https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Parkinsonism due to Manganism in a Welder

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https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Manganese neurotoxicity: a focus on glutamate transporters

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https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

PARK9-LINKED PARKINSONISM IN EASTERN ASIA: MUTATION DETECTION IN ATP13A2 AND CLINICAL PHENOTYPE

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor function

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Common pathogenic effects of missense mutations in the P-type ATPase ATP13A2 (PARK9) associated with early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

X-ray fluorescence imaging: a new tool for studying manganese neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Tissue- and cell-specific mitochondrial defect in Parkin-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Changes in GABA and glutamate concentrations during memory tasks in patients with Parkinson's disease undergoing DBS surgery.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

DMT1: which metals does it transport?

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Lysosomal dysfunction in neurodegeneration: the role of ATP13A2/PARK9.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

PINK1 points Parkin to mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021

Parkin uses the UPS to ship off dysfunctional mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURO.2014.08.006

7 January 2021