Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts (Q35124597)

6 August 2017

title

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts (English)

1 reference

cancer-associated fibroblast

6 August 2017

main subject

1 reference

Ruth C Birbe

7

0 references

Ubaldo E Martinez-Outschoorn

Ubaldo E Martinez-Outschoorn

2

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Anthony Howell

Anthony Howell

8

0 references

Federica Sotgia

12

Federica Sotgia

1 reference

6 August 2017

14

Michael P Lisanti

1 reference

6 August 2017

Diana Whitaker-Menezes

1

Diana Whitaker-Menezes

1 reference

6 August 2017

11

Richard G Pestell

1 reference

6 August 2017

4

Adam Ertel

1 reference

6 August 2017

5

Neal Flomenberg

1 reference

6 August 2017

9

Stephanos Pavlides

1 reference

6 August 2017

10

Ricardo Gandara

1 reference

6 August 2017

13

Nancy J Philp

1 reference

6 August 2017

Zhao Lin

3

1 reference

6 August 2017

Agnieszka K Witkiewicz

6

1 reference

6 August 2017

publication date

1 June 2011

1 reference

6 August 2017

number of pages

12

1 reference

inferred from page(s)

published in

Cell Cycle

1 reference

6 August 2017

volume

10

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6 August 2017

issue

11

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6 August 2017

page(s)

1772-1783

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Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics

6 August 2017

cites work

1 reference

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Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment

28 July 2018

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RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response

28 July 2018

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The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

28 July 2018

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Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

28 July 2018

1 reference

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Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

28 July 2018

1 reference

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Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

28 July 2018

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Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors

28 July 2018

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Oxidative stress promotes myofibroblast differentiation and tumour spreading

28 July 2018

1 reference

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Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

28 July 2018

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Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

28 July 2018

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28 July 2018

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AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10

28 July 2018

1 reference

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The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

28 July 2018

1 reference

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NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury.

28 July 2018

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An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation

28 July 2018

1 reference

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Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

28 July 2018

1 reference

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Stromal cell expression of caveolin-1 predicts outcome in breast cancer

28 July 2018

1 reference

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An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

28 July 2018

1 reference

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A compact VEGF signature associated with distant metastases and poor outcomes

28 July 2018

1 reference

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Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts

28 July 2018

1 reference

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Stromal gene expression predicts clinical outcome in breast cancer

28 July 2018

1 reference

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Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle.

28 July 2018

1 reference

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NCBI GEO: mining tens of millions of expression profiles--database and tools update

28 July 2018

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Redox regulation of the hypoxia-inducible factor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

The molecular portraits of breast tumors are conserved across microarray platforms

28 July 2018

1 reference

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The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

28 July 2018

1 reference

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NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts

28 July 2018

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Monocarboxylate transporters in the central nervous system: distribution, regulation and function.

28 July 2018

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Immunohistochemical analysis of MCT1, MCT2 and MCT4 expression in rat plantaris muscle.

28 July 2018

1 reference

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Severe lactic acidosis in a 14-year-old female with metastatic undifferentiated carcinoma of unknown primary

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse

28 July 2018

1 reference

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ArrayExpress--a public repository for microarray gene expression data at the EBI

28 July 2018

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Lactate shuttles in nature

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

The contribution of astrocytes to the 18F-2-deoxyglucose signal in PET activation studies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Correlation of high lactate levels in head and neck tumors with incidence of metastasis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

An unusual case of shock in a young woman

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Current concepts in lactate exchange

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Lactic acidosis. A presentation of metastatic breast cancer arising in pregnancy.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Type B lactic acidosis and metastatic breast cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Cancer-related issues of CD147.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Role of glutamate in neuron-glia metabolic coupling

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy

27 September 2018

1 reference

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A lactatic perspective on metabolism

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse.

27 September 2018

1 reference

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Lactate: link between glycolytic and oxidative metabolism

27 September 2018

1 reference

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Neuron-glia metabolic coupling and plasticity

27 September 2018

1 reference

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Lactate: mirror and motor of tumor malignancy

27 September 2018

1 reference

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Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis.

27 September 2018

1 reference

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Transport of ketone bodies and lactate in the sheep ruminal epithelium by monocarboxylate transporter 1.

27 September 2018

1 reference

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The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142461

Lactic acidosis associated with metastatic breast carcinoma

27 September 2018

1 reference

12 December 2020

Substrate and inhibitor specificities of the monocarboxylate transporters of single rat heart cells

1 reference

12 December 2020

Lactic acidosis: a metabolic complication of extensive metastatic cancer

1 reference

12 December 2020

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers

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12 December 2020

Identifiers

DOI

10.4161/CC.10.11.15659

1 reference

6 August 2017

1 reference

6 August 2017

1 reference