Targeting programmed cell death in neurodegenerative diseases (Q35120138)

6 August 2017

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title

Targeting programmed cell death in neurodegenerative diseases (English)

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6 August 2017

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2

Serge Przedborski

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6 August 2017

1

Miquel Vila

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12728264

30 December 2023

language of work or name

English

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publication date

1 May 2003

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full work available at URL

6 August 2017

https://www.nature.com/articles/nrn1100.pdf

file format

Portable Document Format

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https://www.nature.com/articles/nrn1100

30 December 2023

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Nature Reviews Neuroscience

30 December 2023

published in

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6 August 2017

volume

4

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6 August 2017

issue

5

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6 August 2017

page(s)

365-375

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An alternative, nonapoptotic form of programmed cell death

6 August 2017

cites work

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Expression of bcl-2 inhibits necrotic neural cell death.

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DNA fragmentation in human substantia nigra: apoptosis or perimortem effect?

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Neuroscience. New leads on the 'how' of Alzheimer's

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Programmed cell death in cerebral ischemia

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Neurodegeneration: what is it and where are we?

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An induced proximity model for caspase-8 activation.

31 March 2020

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

31 March 2020

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BCL-2 family members and the mitochondria in apoptosis

31 March 2020

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

31 March 2020

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Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

31 March 2020

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Inflammation in neurodegenerative disease--a double-edged sword

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

31 March 2020

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Biochemical pathways of caspase activation during apoptosis

31 March 2020

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

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Structural and biochemical basis of apoptotic activation by Smac/DIABLO

31 March 2020

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Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

31 March 2020

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Molecular characterization of mitochondrial apoptosis-inducing factor

31 March 2020

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Endonuclease G is an apoptotic DNase when released from mitochondria

31 March 2020

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Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans

31 March 2020

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

31 March 2020

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An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

31 March 2020

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BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

31 March 2020

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Histochemical detection of apoptosis in Parkinson's disease.

31 March 2020

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A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease.

31 March 2020

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On the question of apoptosis in the parkinsonian substantia nigra

31 March 2020

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Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease

31 March 2020

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Cell death and apoptosis regulating proteins in Parkinson's disease--a cautionary note

31 March 2020

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Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?

31 March 2020

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Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease

31 March 2020

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Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

31 March 2020

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Increased expression and redistribution of the antiapoptotic molecule Bcl-xL in Parkinson's disease

31 March 2020

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Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

31 March 2020

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Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease

31 March 2020

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

31 March 2020

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Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

31 March 2020

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

31 March 2020

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Neuropathology in mice expressing human alpha-synuclein

31 March 2020

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A Drosophila model of Parkinson's disease

31 March 2020

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Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

31 March 2020

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

31 March 2020

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Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

31 March 2020

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In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

31 March 2020

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Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

31 March 2020

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.

31 March 2020

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Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity

31 March 2020

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A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

31 March 2020

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A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism

31 March 2020

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Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

31 March 2020

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p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

31 March 2020

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Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

31 March 2020

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MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

31 March 2020

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Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

31 March 2020

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

31 March 2020

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The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase

31 March 2020

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An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

31 March 2020

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Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

31 March 2020

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Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons.

31 March 2020

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Axonal self-destruction and neurodegeneration

31 March 2020

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Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

31 March 2020

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Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

31 March 2020

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Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.

31 March 2020

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

31 March 2020

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

31 March 2020

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Alpha-synuclein in Lewy bodies

31 March 2020

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Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

31 March 2020

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Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

31 March 2020

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Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

31 March 2020

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Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

31 March 2020

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Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

31 March 2020

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Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole

31 March 2020

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Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

31 March 2020

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Direct evidence for glutathione as mediator of apoptosis in neuronal cells

31 March 2020

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

31 March 2020

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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

31 March 2020

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

31 March 2020

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Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease

31 March 2020

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Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

31 March 2020

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

31 March 2020

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Superoxide dismutase in familial amyotrophic lateral sclerosis: models for gain of function

31 March 2020

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Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

31 March 2020

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Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection

31 March 2020

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Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

31 March 2020

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Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

31 March 2020

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Programmed cell death in amyotrophic lateral sclerosis

31 March 2020

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From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

31 March 2020

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Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism

31 March 2020

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Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis

31 March 2020

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Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

31 March 2020

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31 March 2020

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Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons

31 March 2020

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A study of apoptosis in normal and pathologic nervous tissue after in situ end-labeling of DNA strand breaks

31 March 2020

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Lack of apoptosis in mice with ALS

31 March 2020

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Motor neuronal death in sporadic amyotrophic lateral sclerosis (ALS) is not apoptotic. A comparative study of ALS and chronic aluminium chloride neurotoxicity in New Zealand white rabbits

31 March 2020

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The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis

31 March 2020

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Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons

31 March 2020

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Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

31 March 2020

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Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons. Bcl-2 expression is increased in unaffected post-central gyrus

31 March 2020

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Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway

31 March 2020

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Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis

31 March 2020

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p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis

31 March 2020

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Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator.

31 March 2020

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Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis

31 March 2020

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Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS

31 March 2020

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Inhibition of ICE slows ALS in mice

31 March 2020

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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

31 March 2020

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X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration

31 March 2020

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Programmed cell death of embryonic motoneurons triggered through the Fas death receptor

31 March 2020

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Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.

31 March 2020

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Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration.

31 March 2020

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Trinucleotide repeat length and clinical progression in Huntington's disease

31 March 2020

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

31 March 2020

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DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

31 March 2020

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Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

31 March 2020

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

31 March 2020

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Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

31 March 2020

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Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant.

31 March 2020

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Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

31 March 2020

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Expression of extended polyglutamine sequentially activates initiator and effector caspases

31 March 2020

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Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

31 March 2020

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

31 March 2020

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

31 March 2020

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Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

31 March 2020

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Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

31 March 2020

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

31 March 2020

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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

31 March 2020

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Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.

31 March 2020

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Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

31 March 2020

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Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

31 March 2020

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From bench to clinic with apoptosis-based therapeutic agents

31 March 2020

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Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

31 March 2020

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Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

31 March 2020

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Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

31 March 2020

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In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease

31 March 2020

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Activation of caspase-8 in the Alzheimer's disease brain

31 March 2020

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Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain

31 March 2020

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Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

31 March 2020

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E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

31 March 2020

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Caspase-2 mediates neuronal cell death induced by beta-amyloid

31 March 2020

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

31 March 2020

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

31 March 2020

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

31 March 2020

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MPTP, MPP+ and mitochondrial function

31 March 2020

1 reference

Studies on the characterization of the inhibitory mechanism of 4'-alkylated 1-methyl-4-phenylpyridinium and phenylpyridine analogues in mitochondria and electron transport particles

31 March 2020

1 reference

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

31 March 2020

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Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

31 March 2020

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Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis

31 March 2020

1 reference

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

31 March 2020

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Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis

31 March 2020

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Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

31 March 2020

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Developmental cell death: morphological diversity and multiple mechanisms

31 March 2020

series ordinal

1

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Journal of Pharmacology and Experimental Therapeutics

30 December 2023

61

288

421

MS Saporito

1999

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30 December 2023

Identifiers

DOI

10.1038/NRN1100

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Dimensions Publication ID

6 August 2017

1004087581

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