The development and regulation of gene repair (Q35209965)

7 August 2017

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title

The development and regulation of gene repair (English)

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7 August 2017

Li Liu

1

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7 August 2017

Hetal Parekh-Olmedo

series ordinal

2

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7 August 2017

Eric B Kmiec

series ordinal

3

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7 August 2017

publication date

1 September 2003

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7 August 2017

published in

Nature Reviews Genetics

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7 August 2017

volume

4

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7 August 2017

issue

9

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7 August 2017

page(s)

679-689

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Progress and problems with the use of viral vectors for gene therapy

7 August 2017

cites work

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The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts

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A role for RNA synthesis in homologous pairing events

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RNA facilitates RecA-mediated DNA pairing and strand transfer between molecules bearing limited regions of homology

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Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract

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DNA hybrids stabilized by heterologies

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DNA pairing is an important step in the process of targeted nucleotide exchange

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Harmful potential of viral vectors fuels doubts over gene therapy

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Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing

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Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration

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Recombination induced by triple-helix-targeted DNA damage in mammalian cells

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Triple helix directed psoralen adducts induce a low frequency of recombination in an SV40 shuttle vector

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Short, single-stranded oligonucleotides mediate targeted nucleotide conversion using extracts from isolated liver mitochondria

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Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides

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Re-engineering plant gene targeting

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Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51-DNA complexes

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31 March 2020

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Transcription activates RecA-promoted homologous pairing of nucleosomal DNA.

31 March 2020

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Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids

31 March 2020

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In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement

31 March 2020

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Influence of DNA delivery method on gene targeting frequencies in human cells

31 March 2020

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Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament

31 March 2020

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Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

31 March 2020

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DNA mismatch correction in a defined system

31 March 2020

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Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide

31 March 2020

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Targeted gene conversion in a mammalian CD34+-enriched cell population using a chimeric RNA/DNA oligonucleotide

31 March 2020

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31 March 2020

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Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide

31 March 2020

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In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides

31 March 2020

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31 March 2020

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Homologous recombination based gene therapy

31 March 2020

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In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide

31 March 2020

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Persistent failures in gene repair

31 March 2020

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Recombinant DNA technique and sickle cell anemia research

31 March 2020

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31 March 2020

Gene repair validation

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Genetic repair of mutations in plant cell-free extracts directed by specific chimeric oligonucleotides

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1156

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7 August 2017

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