Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease (Q35244160)

7 August 2017

title

Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease (English)

1 reference

7 August 2017

0 references

Xuesong Chen

1

1 reference

7 August 2017

Jun Wu

2

1 reference

7 August 2017

Yuan Luo

3

1 reference

7 August 2017

Xia Liang

4

1 reference

7 August 2017

Charlene Supnet

5

1 reference

7 August 2017

Mee Whi Kim

6

1 reference

7 August 2017

Gregor P Lotz

7

1 reference

7 August 2017

Guocheng Yang

8

1 reference

7 August 2017

Paul J Muchowski

9

1 reference

7 August 2017

Thomas Kodadek

10

1 reference

7 August 2017

Ilya Bezprozvanny

11

1 reference

7 August 2017

publication date

1 September 2011

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7 August 2017

published in

Chemistry and Biology

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7 August 2017

volume

18

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7 August 2017

issue

9

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7 August 2017

page(s)

1113-1125

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Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment

7 August 2017

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

27 July 2018

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Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

27 July 2018

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Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation

27 July 2018

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A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

27 July 2018

1 reference

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Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody

27 July 2018

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27 July 2018

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Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

27 July 2018

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Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

27 July 2018

1 reference

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Neuropathological classification of Huntington's disease

27 July 2018

1 reference

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27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Secondary Structure of Huntingtin Amino-Terminal Region

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Peptoids as potential therapeutics.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effect on polyglutamine disease mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Protein transduction domain-mediated delivery of QBP1 suppresses polyglutamine-induced neurodegeneration in vivo

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183433

A cell-permeable synthetic transcription factor mimic

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21944750

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21944750

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A toxic monomeric conformer of the polyglutamine protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21944750

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2011.06.010

1 reference

7 August 2017

1 reference

7 August 2017

1 reference