Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth (Q36339227)

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English	Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth	scientific article

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scholarly article

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Europe PubMed Central

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13 August 2017

Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth (English)

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13 August 2017

mitochondrial fission

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Michael P. Lisanti

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Michael P Lisanti

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13 August 2017

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Federica Sotgia

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Federica Sotgia

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13 August 2017

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Diana Whitaker-Menezes

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Diana Whitaker-Menezes

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Teresa A Zimmers

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13 August 2017

Richard Pestell

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Richard G Pestell

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13 August 2017

Ubaldo E Martinez-Outschoorn

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Ubaldo E Martinez-Outschoorn

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13 August 2017

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Anthony Howell

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13 August 2017

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Carmela Guido

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13 August 2017

8

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Saveria Aquila

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13 August 2017

author name string

Zhao Lin

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13 August 2017

Mathew C Casimiro

7

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13 August 2017

Sebastiano Ando'

9

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13 August 2017

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publication date

1 August 2012

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13 August 2017

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13 August 2017

3

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13 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

798-810

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Europe PubMed Central

PMC publication ID

13 August 2017

Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

1 reference

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CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.

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Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

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Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection

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Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis

1 reference

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Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells

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Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".

1 reference

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Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator

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Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

1 reference

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Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

1 reference

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Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics

1 reference

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Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment

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Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

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Why do tumors metastasize?

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Cancer associated fibroblasts stimulated by transforming growth factor beta1 (TGF-beta 1) increase invasion rate of tumor cells: a population study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22878233

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based on heuristic

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Mitochondrial stress signals revise an old aging theory

1 reference

https://pubmed.ncbi.nlm.nih.gov/22878233

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inferred from PubMed ID database lookup

Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22878233

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Power surge: supporting cells "fuel" cancer cell mitochondria

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https://pubmed.ncbi.nlm.nih.gov/22878233

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Identifiers

10.18632/ONCOTARGET.574

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

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