Sterols and oxysterols in immune cell function (Q38130108)

29 August 2017

title

Sterols and oxysterols in immune cell function (English)

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29 August 2017

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Christopher K Glass

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29 August 2017

Nathanael J Spann

1

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29 August 2017

language of work or name

English

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publication date

1 September 2013

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29 August 2017

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29 August 2017

volume

14

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29 August 2017

issue

9

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29 August 2017

page(s)

893-900

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Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

29 August 2017

cites work

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Liver X Receptor Signaling Pathways in Cardiovascular Disease

21 January 2018

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LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

21 January 2018

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Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

21 January 2018

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Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

21 January 2018

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Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

21 January 2018

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Statins enhance formation of phagocyte extracellular traps

21 January 2018

1 reference

The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response

21 January 2018

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Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

21 January 2018

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25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

21 January 2018

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Oxysterols direct immune cell migration via EBI2

21 January 2018

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Oxysterols direct B-cell migration through EBI2

21 January 2018

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The RXR heterodimers and orphan receptors

21 January 2018

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Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells

21 January 2018

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Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

21 January 2018

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Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression

21 January 2018

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Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

21 January 2018

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Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines

21 January 2018

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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

21 January 2018

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

21 January 2018

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LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

21 January 2018

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Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein

21 January 2018

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Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

21 January 2018

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Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule

21 January 2018

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Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes.

21 January 2018

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Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c

21 January 2018

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

21 January 2018

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Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

21 January 2018

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Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

21 January 2018

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Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells

21 January 2018

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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

21 January 2018

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TAM receptors are pleiotropic inhibitors of the innate immune response

21 January 2018

1 reference

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

21 January 2018

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Liver X receptor biology and pharmacology: new pathways, challenges and opportunities.

21 January 2018

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Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

21 January 2018

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Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

21 January 2018

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Liver X receptor β protects dopaminergic neurons in a mouse model of Parkinson disease

21 January 2018

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Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism

21 January 2018

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Liver X Receptor Activation Potentiates the Lipopolysaccharide Response in Human Macrophages

21 January 2018

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Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a.

21 January 2018

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Protein farnesylation and disease

21 January 2018

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Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

21 January 2018

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21 January 2018

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Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

21 January 2018

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Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo.

21 January 2018

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Pleiotropic effects of statins

21 January 2018

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Preadmission use of statins and outcomes after hospitalization with pneumonia: population-based cohort study of 29,900 patients

21 January 2018

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The effect of statins on mortality in patients with bacteremia

21 January 2018

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Statin (cerivastatin) protects mice against sepsis-related death via reduced proinflammatory cytokines and enhanced bacterial clearance

21 January 2018

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HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation

21 January 2018

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Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation

21 January 2018

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Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome

21 January 2018

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Geranylgeraniol regulates negatively caspase-1 autoprocessing: implication in the Th1 response against Mycobacterium tuberculosis

21 January 2018

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

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Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

21 January 2018

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Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

21 January 2018

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LXR-dependent gene expression is important for macrophage survival and the innate immune response

21 January 2018

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Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis

21 January 2018

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ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation

21 January 2018

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Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways.

21 January 2018

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Lipids at the interface of virus-host interactions

21 January 2018

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Oxysterols, but not cholesterol, inhibit human immunodeficiency virus replication in vitro

21 January 2018

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Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus

21 January 2018

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Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner

21 January 2018

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Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection

21 January 2018

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Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1

21 January 2018

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Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice

21 January 2018

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LXR deficiency confers increased protection against visceral Leishmania infection in mice

21 January 2018

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Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons

21 January 2018

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Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide

21 January 2018

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Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis

21 January 2018

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Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses

21 January 2018

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The immunobiology of multiple sclerosis: an autoimmune disease of the central nervous system

21 January 2018

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Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration

21 January 2018

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Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis.

21 January 2018

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Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients

21 January 2018

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Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors

21 January 2018

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Oxysterols as biomarkers in neurodegenerative diseases

21 January 2018

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Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response

21 January 2018

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PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection

21 January 2018

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Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin.

21 January 2018

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Immunosuppressive strategies that are mediated by tumor cells

21 January 2018

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Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

21 January 2018

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LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

21 January 2018

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The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

21 January 2018

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Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase

21 January 2018

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Genomic responses in mouse models poorly mimic human inflammatory diseases

21 January 2018

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Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses

21 January 2018

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12 December 2020

Hydroxymethylglutaryl-coenzyme A reductase inhibition stimulates caspase-1 activity and Th1-cytokine release in peripheral blood mononuclear cells

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12 December 2020

LXR activation reduces proinflammatory cytokine expression in human CD4-positive lymphocytes

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12 December 2020

Statin therapy is associated with fewer deaths in patients with bacteraemia

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12 December 2020

SREBPs: metabolic integrators in physiology and metabolism

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12 December 2020

Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis

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12 December 2020

EBI2 mediates B cell segregation between the outer and centre follicle

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12 December 2020

The coregulator exchange in transcriptional functions of nuclear receptors

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12 December 2020

Identifiers

DOI

10.1038/NI.2681

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Dimensions Publication ID

29 August 2017

1025176997

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