MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling (Q89807991)

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8 April 2020

title

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling (English)

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8 April 2020

17

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8 April 2020

16

Carol Prives

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8 April 2020

10

Joleen M Csuka

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8 April 2020

14

Donald C Lo

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8 April 2020

6

Denise E Dunn

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8 April 2020

author name string

Divya Venkatesh

1

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8 April 2020

Nicholas A O'Brien

2

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8 April 2020

Fereshteh Zandkarimi

3

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8 April 2020

David R Tong

4

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8 April 2020

Michael E Stokes

5

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8 April 2020

Everett S Kengmana

7

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8 April 2020

Allegra T Aron

8

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8 April 2020

Alyssa M Klein

9

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8 April 2020

Sung-Hwan Moon

11

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8 April 2020

Marcus Conrad

12

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8 April 2020

Christopher J Chang

13

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8 April 2020

Angelo D'Alessandro

15

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publication date

20 February 2020

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8 April 2020

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8 April 2020

volume

34

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8 April 2020

issue

7-8

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8 April 2020

page(s)

526-543

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Regulation of triglyceride metabolism by PPARs: fibrates and thiazolidinediones have distinct effects

8 April 2020

cites work

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12 December 2020

Regulation of lipid and lipoprotein metabolism by PPAR activators

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12 December 2020

Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms

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12 December 2020

Function and dysfunction of the human oncoprotein MDM2.

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12 December 2020

p53-Mdm2--the affair that never ends

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12 December 2020

MdmX inhibits Smad transactivation

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12 December 2020

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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12 December 2020

Cell cycle regulatory functions of the human oncoprotein MDM2.

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12 December 2020

p53-independent functions of MDM2.

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12 December 2020

Mdmx and Mdm2: brothers in arms?

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12 December 2020

Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future

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12 December 2020

Pilot screening programme for small molecule activators of p53.

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12 December 2020

Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity

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12 December 2020

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

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12 December 2020

Hdmx modulates the outcome of p53 activation in human tumor cells

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12 December 2020

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

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12 December 2020

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

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12 December 2020

MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice

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12 December 2020

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

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12 December 2020

Peroxisome proliferator activated receptors and lipoprotein metabolism

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12 December 2020

Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation

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12 December 2020

Regulation of peroxisome proliferator-activated receptor-alpha by MDM2.

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12 December 2020

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

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12 December 2020

Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements

1 reference

12 December 2020

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

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12 December 2020

Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay

1 reference

12 December 2020

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

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12 December 2020

A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells

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12 December 2020

The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases

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12 December 2020

MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice.

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12 December 2020

Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay.

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12 December 2020

Ferroptosis: an iron-dependent form of nonapoptotic cell death

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12 December 2020

Identification of FDA-approved drugs that computationally bind to MDM2

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12 December 2020

The Many Faces of MDM2 Binding Partners

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12 December 2020

Mdm2 and MdmX as Regulators of Gene Expression

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12 December 2020

Protecting the genome from mdm2 and mdmx

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12 December 2020

p21WAF1 and tumourigenesis: 20 years after

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12 December 2020

MDM2, MDMX and p53 in oncogenesis and cancer therapy

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12 December 2020

MDM2's social network

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12 December 2020

MDM2 promotes invasion and metastasis in invasive ductal breast carcinoma by inducing matrix metalloproteinase-9.

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12 December 2020

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

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12 December 2020

Mdmx promotes genomic instability independent of p53 and Mdm2.

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12 December 2020

p53-independent effects of Mdm2.

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12 December 2020

Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.

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12 December 2020

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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12 December 2020

E3 ubiquitin ligases as drug targets and prognostic biomarkers in melanoma

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12 December 2020

Ferroptosis as a p53-mediated activity during tumour suppression

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12 December 2020

Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective

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12 December 2020

XI-006 induces potent p53-independent apoptosis in Ewing sarcoma

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12 December 2020

The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer

1 reference

12 December 2020

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

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12 December 2020

High-Throughput Screening of Patient-Derived Cultures Reveals Potential for Precision Medicine in Glioblastoma

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12 December 2020

Ferroptosis: Death by Lipid Peroxidation

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12 December 2020

USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation

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12 December 2020

The Roles of MDM2 and MDMX in Cancer.

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12 December 2020

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

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12 December 2020

MDM2 oligomers: antagonizers of the guardian of the genome

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12 December 2020

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.

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12 December 2020

Mouse double minute 2 (MDM2) upregulates Snail expression and induces epithelial-to-mesenchymal transition in breast cancer cells in vitro and in vivo

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12 December 2020

Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer.

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12 December 2020

Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.

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12 December 2020

Outside the p53 RING: Transcription Regulation by Chromatin-Bound MDM2.

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12 December 2020

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI.

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12 December 2020

The Zn-finger domain of MdmX suppresses cancer progression by promoting genome stability in p53-mutant cells

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12 December 2020

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

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12 December 2020

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

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12 December 2020

An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells

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12 December 2020

Ironing out how p53 regulates ferroptosis

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12 December 2020

The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis

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12 December 2020

Mdm2 as a chromatin modifier

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12 December 2020

Role of MDM2 and MDMX in DNA repair

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12 December 2020

MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability

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12 December 2020

PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C.

1 reference

12 December 2020

Reactive Oxygen Species-Mediated Cellular Stress Response and Lipid Accumulation in Oleaginous Microorganisms: The State of the Art and Future Perspectives

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12 December 2020

Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure

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12 December 2020

Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells

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12 December 2020

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

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12 December 2020

MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells

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12 December 2020

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

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12 December 2020

Impaired β-Oxidation and Altered Complex Lipid Fatty Acid Partitioning with Advancing CKD.

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12 December 2020

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

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12 December 2020

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.

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12 December 2020

Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects

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12 December 2020

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

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12 December 2020

Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening

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12 December 2020

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

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12 December 2020

BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression

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12 December 2020

Untargeted and Semi-targeted Lipid Analysis of Biological Samples Using Mass Spectrometry-Based Metabolomics

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12 December 2020

FSP1 is a glutathione-independent ferroptosis suppressor

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12 December 2020

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

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12 December 2020

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

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12 December 2020

Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery

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12 December 2020