Pages that link to "Q30986734"
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The following pages link to Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides (Q30986734):
Displaying 35 items.
- Alzheimer's therapeutics: translation of preclinical science to clinical drug development (Q26829267) (← links)
- Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation (Q28252132) (← links)
- Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease (Q28363447) (← links)
- Modulators of γ-secretase activity can facilitate the toxic side-effects and pathogenesis of Alzheimer's disease (Q28484883) (← links)
- Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane (Q28568133) (← links)
- Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludis (Q28830254) (← links)
- Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death (Q30566020) (← links)
- Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels (Q33496258) (← links)
- PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling (Q33947097) (← links)
- A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity (Q33991052) (← links)
- Gamma-secretase inhibitors and Alzheimer's disease (Q34161046) (← links)
- Aspartic proteases involved in Alzheimer's disease (Q35125093) (← links)
- The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism (Q35578655) (← links)
- γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). (Q35871906) (← links)
- Presenilin function and gamma-secretase activity (Q36109130) (← links)
- Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis (Q36478423) (← links)
- A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis (Q36690193) (← links)
- In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects (Q36729084) (← links)
- Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production. (Q37048107) (← links)
- Current concepts in Alzheimer's disease: a multidisciplinary review (Q37360292) (← links)
- Endocytosis and intracellular trafficking of Notch and its ligands (Q37785196) (← links)
- The multiple facets of ubiquitination in the regulation of notch signaling pathway. (Q37804446) (← links)
- Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1. (Q38737484) (← links)
- Interplay between α-, β-, and γ-secretases determines biphasic amyloid-β protein level in the presence of a γ-secretase inhibitor. (Q39244758) (← links)
- Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment (Q39451354) (← links)
- Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease. (Q39733364) (← links)
- The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression (Q39968931) (← links)
- Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. (Q40447332) (← links)
- Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation (Q40547989) (← links)
- Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation (Q40601680) (← links)
- gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta. (Q40674165) (← links)
- Identification and characterization of presenilin-independent Notch signaling (Q40760805) (← links)
- The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors (Q44420427) (← links)
- Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein (Q51837859) (← links)
- Cleavage of E-cadherin: a mechanism for disruption of the intestinal epithelial barrier by Candida albicans. (Q52577946) (← links)