Pages that link to "Q34998181"
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The following pages link to A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport (Q34998181):
Displaying 50 items.
- TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA (Q24338199) (← links)
- Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders (Q26828357) (← links)
- Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity (Q27301865) (← links)
- TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans (Q27332459) (← links)
- TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets (Q28080628) (← links)
- A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration (Q28488462) (← links)
- Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice (Q30541711) (← links)
- Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm (Q30559680) (← links)
- Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species (Q30574024) (← links)
- Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions (Q30661910) (← links)
- Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress (Q31122876) (← links)
- Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins (Q33622382) (← links)
- The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. (Q34263380) (← links)
- Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination (Q34285952) (← links)
- Inhibition of TDP-43 aggregation by nucleic acid binding (Q34758540) (← links)
- RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43. (Q34806194) (← links)
- Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins (Q35111101) (← links)
- Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration (Q35674883) (← links)
- Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration (Q35773678) (← links)
- Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice (Q36201764) (← links)
- Pharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications (Q36269224) (← links)
- Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission? (Q36601641) (← links)
- Prions and the potential transmissibility of protein misfolding diseases (Q36667738) (← links)
- The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates (Q36724968) (← links)
- Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation (Q36748388) (← links)
- Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43) (Q36873601) (← links)
- Structural transformation of the amyloidogenic core region of TDP-43 protein initiates its aggregation and cytoplasmic inclusion (Q37000560) (← links)
- Disease animal models of TDP-43 proteinopathy and their pre-clinical applications (Q37291234) (← links)
- Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. (Q37451385) (← links)
- TDP-43 autoregulation: implications for disease (Q37890940) (← links)
- RNA-binding proteins with prion-like domains in ALS and FTLD-U. (Q37918720) (← links)
- Progranulin and TDP-43: mechanistic links and future directions (Q37921642) (← links)
- Protein misdirection inside and outside motor neurons in Amyotrophic Lateral Sclerosis (ALS): a possible clue for therapeutic strategies (Q37954610) (← links)
- Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation? (Q38006463) (← links)
- Protein truncation as a common denominator of human neurodegenerative foldopathies (Q38091670) (← links)
- From nucleation to widespread propagation: A prion-like concept for ALS. (Q38345753) (← links)
- Old versus New Mechanisms in the Pathogenesis of ALS. (Q38700722) (← links)
- Physiological functions and clinical implications of the N-end rule pathway (Q38919056) (← links)
- Prion-like propagation as a pathogenic principle in frontotemporal dementia. (Q38922025) (← links)
- Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy (Q38949000) (← links)
- TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1. (Q38985711) (← links)
- Interactions of pathological proteins in neurodegenerative diseases (Q39236779) (← links)
- The seeds of neurodegeneration: prion-like spreading in ALS (Q39247056) (← links)
- TDP-43 and Cytoskeletal Proteins in ALS. (Q39279950) (← links)
- ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications (Q39319522) (← links)
- Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway (Q40267721) (← links)
- The N-terminal dimerization is required for TDP-43 splicing activity (Q41094549) (← links)
- Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region (Q41819989) (← links)
- Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked mutant TDP-43 proteins (Q43119425) (← links)
- Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. (Q46031626) (← links)