Regulating the p53 pathway: in vitro hypotheses, in vivo veritas (Q29615658)

Europe PubMed Central

title

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas (English)

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30 April 2017

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Toledo F

1

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30 April 2017

Wahl GM

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17128209

30 April 2017

language of work or name

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30 April 2017

publication date

December 2006

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30 April 2017

published in

Nature Reviews Cancer

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30 April 2017

volume

6

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30 April 2017

issue

12

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30 April 2017

page(s)

909-23

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p53 has a direct apoptogenic role at the mitochondria

30 April 2017

cites work

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PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

1 May 2017

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Live or let die: the cell's response to p53

1 May 2017

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The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis

1 May 2017

1 reference

Regulation of p53 activity through lysine methylation

1 May 2017

1 reference

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

1 May 2017

1 reference

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

1 May 2017

1 reference

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 May 2017

1 reference

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

1 May 2017

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p53 isoforms can regulate p53 transcriptional activity.

1 May 2017

1 reference

The language of covalent histone modifications

1 May 2017

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 May 2017

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 May 2017

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

1 May 2017

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Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

1 May 2017

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Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth

1 May 2017

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Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

1 May 2017

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Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

1 May 2017

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DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

1 May 2017

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 May 2017

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Hdmx modulates the outcome of p53 activation in human tumor cells

1 May 2017

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Critical role for Daxx in regulating Mdm2

1 May 2017

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Medical genetics: a marker for Stevens-Johnson syndrome

1 May 2017

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

1 May 2017

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The ubiquitin ligase COP1 is a critical negative regulator of p53

1 May 2017

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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

1 May 2017

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Identification of a novel p53 functional domain that is necessary for efficient growth suppression

1 May 2017

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 May 2017

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 May 2017

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Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma

1 May 2017

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The common and distinct target genes of the p53 family transcription factors

1 May 2017

1 reference

p53 and metabolism: Inside the TIGAR.

31 March 2020

1 reference

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

31 March 2020

1 reference

The MDM2 gene amplification database

31 March 2020

1 reference

Regulation of p53 function and stability by phosphorylation

31 March 2020

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Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

31 March 2020

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Post-translational modification of p53 in tumorigenesis

31 March 2020

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p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.

31 March 2020

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Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.

31 March 2020

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HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage

31 March 2020

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Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

31 March 2020

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DNA damage activates p53 through a phosphorylation-acetylation cascade

31 March 2020

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A transactivation-deficient mouse model provides insights into Trp53 regulation and function

31 March 2020

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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

31 March 2020

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

31 March 2020

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The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

31 March 2020

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Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo

31 March 2020

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Explaining the biological activity of transactivation-deficient p53 variants.

31 March 2020

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Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses

31 March 2020

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Phosphorylation of serine 18 regulates distinct p53 functions in mice

31 March 2020

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Mutation of mouse p53 Ser23 and the response to DNA damage

31 March 2020

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Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

31 March 2020

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Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

31 March 2020

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Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

31 March 2020

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The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

31 March 2020

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Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

31 March 2020

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A Role for the Polyproline Domain of p53 in Its Regulation by Mdm2

31 March 2020

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Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage

31 March 2020

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The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53

31 March 2020

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A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

31 March 2020

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The polyproline region of p53 is required to activate apoptosis but not growth arrest.

31 March 2020

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Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

31 March 2020

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Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain

31 March 2020

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The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

31 March 2020

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The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions.

31 March 2020

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Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

31 March 2020

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Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

31 March 2020

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Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

31 March 2020

1 reference

The IARC TP53 database: new online mutation analysis and recommendations to users

31 March 2020

1 reference

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

31 March 2020

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

31 March 2020

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

31 March 2020

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Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

31 March 2020

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Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s

31 March 2020

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Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

31 March 2020

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MdmX protects p53 from Mdm2-mediated degradation

31 March 2020

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Mdmx as an essential regulator of p53 activity

31 March 2020

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Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

31 March 2020

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HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

31 March 2020

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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

31 March 2020

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Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development

31 March 2020

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DNA damage-induced MDMX degradation is mediated by MDM2.

31 March 2020

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

31 March 2020

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ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

31 March 2020

1 reference

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

31 March 2020

1 reference

Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.

31 March 2020

1 reference

Molecular biology of human papillomavirus infection and cervical cancer

31 March 2020

1 reference

Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus

31 March 2020

1 reference

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

31 March 2020

1 reference

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

31 March 2020

1 reference

Real-time quantitative PCR analysis of regions involved in gene amplification reveals gene overdose in low-grade astrocytic gliomas.

31 March 2020

1 reference

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

31 March 2020

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MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

31 March 2020

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Comparative study of the p53-mdm2 and p53-MDMX interfaces

31 March 2020

1 reference

Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations

31 March 2020

1 reference

Tumour suppression: disruption of HAUSP gene stabilizes p53

31 March 2020

1 reference

RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses

31 March 2020

1 reference

Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein

31 March 2020

1 reference

p53 linear diffusion along DNA requires its C terminus

31 March 2020

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Regulation of DNA binding of p53 by its C-terminal domain.

31 March 2020

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

31 March 2020

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A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

31 March 2020

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Phosphorylation of p53 serine 15 increases interaction with CBP

31 March 2020

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Transcriptional regulation by p53: one protein, many possibilities

31 March 2020

1 reference

Real-time quantitative PCR analysis of gene dosages reveals gene amplification in low-grade oligodendrogliomas.

31 March 2020

1 reference

The p53/Mdm2/p14ARF cell cycle control pathway genes may be inactivated by genetic and epigenetic mechanisms in gliomas.

31 March 2020

1 reference

Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components

31 March 2020

1 reference

Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target

31 March 2020

1 reference

Molecular analysis for p53 and mdm2 in intracranial germ cell tumors

31 March 2020

1 reference

Gliomatosis cerebri: molecular pathology and clinical course

31 March 2020

1 reference

MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data

31 March 2020

1 reference

Genetic alterations of the p14ARF -hdm2-p53 regulatory pathway in breast carcinoma.

31 March 2020

1 reference

Amplification of the mdm-2 gene and p53 abnormalities in uterine sarcomas

31 March 2020

1 reference

Locus-specific multifluor FISH analysis allows physical characterization of complex chromosome abnormalities in neoplasia

31 March 2020

1 reference

Characterization of chromosome aberrations in salivary gland tumors by FISH, including multicolor COBRA-FISH

31 March 2020

1 reference

Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma

31 March 2020

1 reference

TP53 mutations and MDM2 gene amplification in squamous-cell carcinomas of the esophagus in south Thailand

31 March 2020

1 reference

Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH.

31 March 2020

1 reference

Mdm2 gene amplification in gastric cancer correlation with expression of Mdm2 protein and p53 alterations

31 March 2020

1 reference

Genetic alterations and oxidative metabolism in sporadic colorectal tumors from a Spanish community

31 March 2020

1 reference

Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer

31 March 2020

1 reference

Gains of 12q13-14 and overexpression of mdm2 are frequent findings in intimal sarcomas of the pulmonary artery.

31 March 2020

1 reference

MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC).

31 March 2020

1 reference

Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors

31 March 2020

1 reference

Chromosomal organization of amplified chromosome 12 sequences in mesenchymal tumors detected by fluorescence in situ hybridization

31 March 2020

1 reference

Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma.

31 March 2020

1 reference

CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons

31 March 2020

1 reference

Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas

31 March 2020

1 reference

Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws

31 March 2020

1 reference

Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma

31 March 2020

1 reference

Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years

31 March 2020

1 reference

Genomic profiling of bone and soft tissue tumors with supernumerary ring chromosomes using tiling resolution bacterial artificial chromosome microarrays

31 March 2020

1 reference

Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis.

31 March 2020

1 reference

The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma.

31 March 2020

1 reference

Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours

31 March 2020

1 reference

Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases

31 March 2020

1 reference

Cytogenetic and molecular genetic analysis of a pediatric pleomorphic sarcoma reveals similarities to adult malignant fibrous histiocytoma

31 March 2020

1 reference

The use of clustering software for the classification of comparative genomic hybridization data. an analysis of 109 malignant fibrous histiocytomas

31 March 2020

1 reference

Gains of 12q are the most frequent genomic imbalances in adult fibrosarcoma and are correlated with a poor outcome.

31 March 2020

1 reference

Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma

31 March 2020

1 reference

Loss of Heterozygosity at 12q14-15 Often Occurs in Stage I Soft Tissue Sarcomas and Is Associated with MDM2 Amplification in Tumors at Various Stages

31 March 2020

1 reference

Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasms.

31 March 2020

1 reference

CDK4andMDM2Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-typeINK4a/ARFLocus

31 March 2020

1 reference

MDM2 gene amplification and lack of p53 point mutations in Hodgkin and Reed-Sternberg cells: results from single-cell polymerase chain reaction and molecular cytogenetic studies

31 March 2020

1 reference

Amplification of CDK4 and MDM2 in malignant melanoma.

31 March 2020

1 reference

Global cancer statistics, 2002

31 March 2020

1 reference

HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma

31 March 2020

1 reference

12 December 2020

Substitutions that compromise the ionizing radiation-induced association of p53 with 14-3-3 proteins also compromise the ability of p53 to induce cell cycle arrest.

1 reference

12 December 2020

Alterations in the p53 and MDM-2 genes are infrequent in clinically localized, stage B prostate adenocarcinomas

1 reference

12 December 2020

Amplification and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas

1 reference

12 December 2020

MDMX: a novel p53-binding protein with some functional properties of MDM2

1 reference

12 December 2020

A comparative study of P53/MDM2 genes alterations and P53/MDM2 proteins immunoreactivity in liver cirrhosis and hepatocellular carcinoma

1 reference

12 December 2020

Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.

1 reference

12 December 2020

p53-dependent growth arrest following calcium phosphate-mediated transfection of murine fibroblasts.

1 reference

12 December 2020

Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover

1 reference

12 December 2020

Abnormalities of the P53, MDM2, BCL2 and BAX genes in acute leukemias.

1 reference

12 December 2020

Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets

1 reference

12 December 2020

Hdmx stabilizes Mdm2 and p53

1 reference

12 December 2020

Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors

1 reference

12 December 2020

Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein

1 reference

12 December 2020

Comparative genomic hybridization of low-grade central osteosarcoma

1 reference

12 December 2020

Absence of amplification of MDM2 gene, a regulator of p53 function, in myelodysplastic syndromes

1 reference

12 December 2020

Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers

1 reference

12 December 2020

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression

1 reference

12 December 2020

mdmx is a negative regulator of p53 activity in vivo

1 reference

12 December 2020

Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.

1 reference

12 December 2020

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Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1001986987

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PubMed publication ID

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30 April 2017

Consolidated OpenCitations Corpus – April 2017