New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy (Q34368970)

1 August 2017

1 reference

title

New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy (English)

1 reference

1 August 2017

0 references

20 October 2014

1 reference

25368578

Frontiers in Aging Neuroscience

1 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25368578%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25368578%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

290

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25368578%20AND%20SRC:MED&resulttype=core&format=json

Cilostazol improves cognitive function in patients with mild cognitive impairment: a retrospective analysis

7 June 2020

cites work

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6 July 2018

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Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs

6 July 2018

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Brain metabolite clearance: impact on Alzheimer's disease

6 July 2018

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Cilostazol add-on therapy in patients with mild dementia receiving donepezil: a retrospective study

6 July 2018

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Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline

6 July 2018

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Effect of TTP488 in patients with mild to moderate Alzheimer's disease

6 July 2018

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Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: targeting for cilostazol

6 July 2018

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Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation

6 July 2018

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Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain

6 July 2018

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Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.

6 July 2018

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6 July 2018

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Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre

6 July 2018

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Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models

6 July 2018

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Neuroscience. Garbage truck of the brain

6 July 2018

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Is there a cerebral lymphatic system?

6 July 2018

1 reference

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Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"

6 July 2018

1 reference

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Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"

6 July 2018

1 reference

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Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions

6 July 2018

1 reference

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Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

6 July 2018

1 reference

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Review: cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy

6 July 2018

1 reference

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Estimating cerebral microinfarct burden from autopsy samples

6 July 2018

1 reference

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Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

6 July 2018

1 reference

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In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI

6 July 2018

1 reference

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A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

6 July 2018

1 reference

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Does vascular pathology contribute to Alzheimer changes?

6 July 2018

1 reference

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The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease

6 July 2018

1 reference

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Somatostatin receptor subtype-4 agonist NNC 26-9100 decreases extracellular and intracellular Aβ₁₋₄₂ trimers

6 July 2018

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Protection by cilostazol against amyloid-β(1-40)-induced suppression of viability and neurite elongation through activation of CK2α in HT22 mouse hippocampal cells

6 July 2018

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A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

6 July 2018

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Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

6 July 2018

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Cerebral microinfarcts: the invisible lesions

6 July 2018

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

6 July 2018

1 reference

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RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer's disease

6 July 2018

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Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia

6 July 2018

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Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

6 July 2018

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Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study

6 July 2018

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Cerebrovascular lesions induce transient β-amyloid deposition

6 July 2018

1 reference

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Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum

6 July 2018

1 reference

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Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

6 July 2018

1 reference

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Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial

6 July 2018

1 reference

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Cilostazol, not aspirin, reduces ischemic brain injury via endothelial protection in spontaneously hypertensive rats

6 July 2018

1 reference

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Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA

6 July 2018

1 reference

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Decreased clearance of CNS beta-amyloid in Alzheimer's disease

6 July 2018

1 reference

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Cilostazol prevents amyloid β peptide25‐35‐induced memory impairment and oxidative stress in mice

6 July 2018

1 reference

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Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

6 July 2018

1 reference

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Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

6 July 2018

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Caffeine as a protective factor in dementia and Alzheimer's disease

6 July 2018

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Pathophysiology of the lymphatic drainage of the central nervous system: Implications for pathogenesis and therapy of multiple sclerosis

6 July 2018

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Changing perspectives regarding late-life dementia.

6 July 2018

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Alzheimer's disease is type 3 diabetes-evidence reviewed

6 July 2018

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Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake

6 July 2018

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Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes

6 July 2018

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Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy

6 July 2018

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Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice

6 July 2018

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Classification and basic pathology of Alzheimer disease

6 July 2018

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

6 July 2018

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Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease

6 July 2018

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Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice

6 July 2018

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The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha

6 July 2018

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Vascular risk factors and dementia: how to move forward?

6 July 2018

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Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study

6 July 2018

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Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition

6 July 2018

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Lymphatic drainage of the brain and the pathophysiology of neurological disease

6 July 2018

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Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.

6 July 2018

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The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease

6 July 2018

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The potential of caffeine for functional modification from cortical synapses to neuron networks in the brain

6 July 2018

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Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

6 July 2018

1 reference

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Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease.

6 July 2018

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Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

6 July 2018

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Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP.

6 July 2018

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Cilostazol attenuates MCP-1 and MMP-9 expression in vivo in LPS-administrated balloon-injured rabbit aorta and in vitro in LPS-treated monocytic THP-1 cells

6 July 2018

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Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

6 July 2018

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Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy

6 July 2018

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Pharmacodynamic interaction studies of Ginkgo biloba with cilostazol and clopidogrel in healthy human subjects

6 July 2018

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Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production

6 July 2018

1 reference

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Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis

6 July 2018

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The cerebral beta-amyloid angiopathies: hereditary and sporadic

6 July 2018

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Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

6 July 2018

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

6 July 2018

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Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease

6 July 2018

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The phosphodiesterase 3 inhibitor cilostazol dilates large cerebral arteries in humans without affecting regional cerebral blood flow.

6 July 2018

1 reference

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Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

6 July 2018

1 reference

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Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression

6 July 2018

1 reference

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LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

6 July 2018

1 reference

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Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement.

6 July 2018

1 reference

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Neurovascular regulation in the normal brain and in Alzheimer's disease

6 July 2018

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Insulin and neurodegenerative disease: shared and specific mechanisms

6 July 2018

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Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

6 July 2018

1 reference

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Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

6 July 2018

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

6 July 2018

1 reference

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Cilostazol represses vascular cell adhesion molecule-1 gene transcription via inhibiting NF-kappaB binding to its recognition sequence

6 July 2018

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Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

6 July 2018

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Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

6 July 2018

1 reference

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

6 July 2018

1 reference

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Antiplatelet therapy using cilostazol, a specific PDE3 inhibitor

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer's disease

6 July 2018

1 reference

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6 July 2018

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

6 July 2018

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6 July 2018

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Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease

6 July 2018

1 reference

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6 July 2018

1 reference

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Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit

6 July 2018

1 reference

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Drainage of interstitial fluid from different regions of rat brain

6 July 2018

1 reference

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The absorption, distribution and excretion of a new antithrombotic and vasodilating agent, cilostazol, in rat, rabbit, dog and man.

6 July 2018

1 reference

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Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin

6 July 2018

1 reference

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Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia

6 July 2018

1 reference

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6 July 2018

1 reference

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

6 July 2018

1 reference

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Albumin outflow into deep cervical lymph from different regions of rabbit brain

6 July 2018

1 reference

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Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain

6 July 2018

1 reference

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Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain

6 July 2018

1 reference

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A combination therapy of donepezil and cilostazol for patients with moderate Alzheimer disease: pilot follow-up study

6 July 2018

1 reference

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Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study.

21 January 2018

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Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries

21 January 2018

1 reference

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RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

21 January 2018

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Treatment of vascular risk factors is associated with slower decline in Alzheimer disease

21 January 2018

1 reference

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RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease

21 January 2018

1 reference

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Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme

21 January 2018

1 reference

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Effect of cilostazol in acute lacunar infarction based on pulsatility index of transcranial Doppler (ECLIPse): a multicenter, randomized, double-blind, placebo-controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00290

Cilostazol inhibits cytokine-induced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells

21 January 2018

1 reference

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Metabolic regulation of brain Abeta by neprilysin

21 January 2018

1 reference

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Dementia: Vascular and neurodegenerative pathways-will they meet?

21 January 2018

1 reference

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Cilostazol reduces the risk of hemorrhagic infarction after administration of tissue-type plasminogen activator in a murine stroke model

21 January 2018

1 reference

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Cilostazol improves lymphatic function by inducing proliferation and stabilization of lymphatic endothelial cells.

21 January 2018

1 reference

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Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice

21 January 2018

1 reference

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Effects of cilostazol on oxidative stress, systemic cytokine release, and spinal cord injury in a rat model of transient aortic occlusion.

21 January 2018

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Association at LRP gene locus with sporadic late-onset Alzheimer's disease.

21 January 2018

1 reference

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Cilostazol preserves CA1 hippocampus and enhances generation of immature neuroblasts in dentate gyrus after transient forebrain ischemia in rats

21 January 2018

1 reference

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

21 January 2018

1 reference

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Effect of cilostazol administration on cerebral hemodynamics and rehabilitation outcomes in poststroke patients.

21 January 2018

1 reference

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Effects of cilostazol on cerebral blood flow, P300, and serum lipid levels in the chronic stage of cerebral infarction

21 January 2018

1 reference

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Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00290

Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia

21 January 2018

1 reference

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Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

21 January 2018

1 reference

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Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.

21 January 2018

1 reference

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Angiotensin converting enzyme (ACE) inhibitors modulate the rate of progression of amnestic mild cognitive impairment.

21 January 2018

1 reference

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Effects of cilostazol on cognition and regional cerebral blood flow in patients with Alzheimer's disease and cerebrovascular disease: a pilot study.

21 January 2018

1 reference

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Mechanisms to explain the reverse perivascular transport of solutes out of the brain.

21 January 2018

1 reference

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Mixed brain pathologies account for most dementia cases in community-dwelling older persons

21 January 2018

1 reference

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Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial

21 January 2018

1 reference

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Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease

21 January 2018

1 reference

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Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia

21 January 2018

1 reference

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Subcellular localization of the low density lipoprotein receptor-related protein (alpha 2-macroglobulin receptor) in human brain.

21 January 2018

1 reference

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Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

21 January 2018

1 reference

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Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00290

Cilostazol improves hippocampus-dependent long-term memory in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00290

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00290

Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice

21 January 2018

1 reference

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Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition

21 January 2018

1 reference

12 December 2020

Binswanger's encephalopathy: serial sections and morphometry of the cerebral arteries

1 reference

12 December 2020

Benefit of cilostazol in patients with high risk of bleeding: subanalysis of cilostazol stroke prevention study 2

1 reference

12 December 2020

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

1 reference

12 December 2020

Genetic-morphologic association study: association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy

1 reference

12 December 2020

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

1 reference

12 December 2020

Cilostazol stroke prevention study: A placebo-controlled double-blind trial for secondary prevention of cerebral infarction

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Identifiers

DOI

10.3389/FNAGI.2014.00290

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25368578%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25368578%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

25368578

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25368578%20AND%20SRC:MED&resulttype=core&format=json