Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination (Q40156233)

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scientific article published on 5 October 2004

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English	Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination	scientific article published on 5 October 2004

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scholarly article

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Europe PubMed Central

PMC publication ID

18 September 2017

Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination (English)

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Europe PubMed Central

PMC publication ID

18 September 2017

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author name string

Luciana Ferrara

1

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Europe PubMed Central

PMC publication ID

18 September 2017

Eric B Kmiec

2

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Europe PubMed Central

PMC publication ID

18 September 2017

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publication date

5 October 2004

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Europe PubMed Central

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18 September 2017

Nucleic Acids Research

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Europe PubMed Central

PMC publication ID

18 September 2017

32

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Europe PubMed Central

PMC publication ID

18 September 2017

17

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

5239-5248

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Enhanced oligonucleotide-directed gene targeting in mammalian cells following treatment with DNA damaging agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521643

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Genetic re-engineering of Saccharomyces cerevisiae RAD51 leads to a significant increase in the frequency of gene repair in vivo

1 reference

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Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.

1 reference

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The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells

1 reference

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Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells

1 reference

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Vanillins--a novel family of DNA-PK inhibitors

1 reference

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Branched oligonucleotides induce in vivo gene conversion of a mutated EGFP reporter

1 reference

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The development and regulation of gene repair

1 reference

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Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration

1 reference

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RAD51 is involved in repair of damage associated with DNA replication in mammalian cells

1 reference

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Targeted nucleotide repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides

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Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3.

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Cell cycle modulation of gene targeting by a triple helix-forming oligonucleotide.

1 reference

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Mechanisms underlying targeted gene correction using chimeric RNA/DNA and single-stranded DNA oligonucleotides

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CHK1-regulated S-phase checkpoint response reduces camptothecin cytotoxicity

1 reference

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Rad51p and Rad54p, but not Rad52p, elevate gene repair in Saccharomyces cerevisiae directed by modified single-stranded oligonucleotide vectors

1 reference

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In vivo gene repair of point and frameshift mutations directed by chimeric RNA/DNA oligonucleotides and modified single-stranded oligonucleotides

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Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle

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Characterization of homologous recombination induced by replication inhibition in mammalian cells

1 reference

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In vitro and in vivo nucleotide exchange directed by chimeric RNA/DNA oligonucleotides in Saccharomyces cerevisae

1 reference

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Tumor cell death induced by topoisomerase-targeting drugs.

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Mechanisms of DNA topoisomerase I-induced cell killing in the yeast Saccharomyces cerevisiae

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22 September 2017

RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors

1 reference

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22 September 2017

Topoisomerase I-mediated DNA damage

1 reference

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22 September 2017

The Saccharomyces cerevisiae Msh2 mismatch repair protein localizes to recombination intermediates in vivo.

1 reference

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22 September 2017

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

1 reference

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22 September 2017

Homologous and non-homologous recombination differentially affect DNA damage repair in mice

1 reference

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Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

1 reference

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Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin

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Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs

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Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

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Homology-directed repair is a major double-strand break repair pathway in mammalian cells

1 reference

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Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells

1 reference

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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

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Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

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Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA.

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Repair of site-specific double-strand breaks in a mammalian chromosome by homologous and illegitimate recombination

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Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes

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Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

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Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

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Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks

1 reference

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Inhibitors of DNA topoisomerases

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DNA topoisomerase poisons as antitumor drugs

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Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA.

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Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53.

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DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells

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Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.

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Interactive competition between homologous recombination and non-homologous end joining

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Gene amplification in a single cell cycle in Chinese hamster ovary cells.

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10.1093/NAR/GKH822

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

ResearchGate publication ID

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